Invitrogen™ PIK3CG Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121025

Catalog No. PIPA5121025

Description

Positive test controls include: Jurkat, K-562, Mouse thymus. The target is usually found in the following locations: Cell membrane, Cytoplasm. Immunogen sequence: RSPGQIHLVQ RHPPSEESQA FQRQLTALIG YDVTDVSNVH DDELEFTRRG LVTPRMAEVA SRDPKLYAMH PWVTSKPLPE YLWKKIANNC IFIVIHRSTT SQTIKVSPDD TPGAILQSFF TKMAKKKSLM DIPESQSEQD FVLRVCGRDE YLVGETPIKN FQWVRHCLKN GEEIHVVLDT PPDPALDEVR KEEWPLVDDC TGVTGYHEQL TIH.

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

Specifications

• Antigen: PIK3CG
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PIK3CG
• Gene Alias: 1-phosphatidylinositol 3-kinase; 5830428L06Rik; EGK_14026; p110gamma; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase gamma catalytic subunit; phosphoinositide-3-kinase, catalytic, gamma polypeptide; PI3CG; PI3K; pi3kcg; Pi3kg1; PI3Kgamma; PI3K-gamma; PI3-kinase subunit gamma; PIK3; Pik3cg; ptdIns-3-kinase subunit gamma; ptdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 298947, 30955, 5294
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.99 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P48736, Q9JHG7
• Gene Symbols: PIK3CG
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 130-342 of human PIK3CG (NP_002640.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG