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Invitrogen™ PILRA Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547613

Catalog No. PIPA547613


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Description

Description

In Western blots, approximately 20% cross-reactivity with recombinant mouse PILR-beta is observed and 5% cross-reactivity with recombinant human PILR-alpha is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILR beta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR alpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PILRA
Polyclonal
Unconjugated
PILRA
AV021745; cell surface receptor FDF03; FDF03; Inhibitory receptor PILR-alpha; paired immunoglobin like type 2 receptor alpha; paired immunoglobin-like type 2 receptor alpha; paired immunoglobulin-like type 2 receptor alpha; Pilra
Goat
Antigen affinity chromatography
RUO
231805
-20°C, Avoid Freeze/Thaw Cycles
Lyophilized
Flow Cytometry, Western Blot
0.2 mg/mL
PBS with 5% trehalose and No Preservative
Q2YFS3
PILRA
Mouse myeloma cell line NS0-derived recombinant mouse PILR-alpha isoform 1 Leu21-Val197.
100 μg
Primary
Mouse
Antibody
IgG
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