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Invitrogen™ PILRA Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA547613
Description
In Western blots, approximately 20% cross-reactivity with recombinant mouse PILR-beta is observed and 5% cross-reactivity with recombinant human PILR-alpha is observed. Reconstitute at 0.2 mg/mL in sterile PBS.
SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILR beta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR alpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.
Specifications
PILRA | |
Polyclonal | |
Unconjugated | |
PILRA | |
AV021745; cell surface receptor FDF03; FDF03; Inhibitory receptor PILR-alpha; paired immunoglobin like type 2 receptor alpha; paired immunoglobin-like type 2 receptor alpha; paired immunoglobulin-like type 2 receptor alpha; Pilra | |
Goat | |
Antigen affinity chromatography | |
RUO | |
231805 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Flow Cytometry, Western Blot | |
0.2 mg/mL | |
PBS with 5% trehalose and No Preservative | |
Q2YFS3 | |
PILRA | |
Mouse myeloma cell line NS0-derived recombinant mouse PILR-alpha isoform 1 Leu21-Val197. | |
100 μg | |
Primary | |
Mouse | |
Antibody | |
IgG |
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