Invitrogen™ PIMT Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA543252

Catalog No. PIPA543252

Description

Peptide sequence: IDENPASDFD DSGSLLGFKY GSGQKYGGIP NFSHRQVRYL EKNVKLKSKY Sequence homology: Cow: 92%; Dog: 92%; Guinea Pig: 93%; Horse: 85%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 93%.

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. [UniProt].

Specifications

• Antigen: PIMT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TGS1
• Gene Alias: Cap-specific guanine-N2 methyltransferase; CLL-associated antigen KW-2; D4Ertd800e; HCA137; Hepatocellular carcinoma-associated antigen 137; LOW QUALITY PROTEIN: trimethylguanosine synthase; NCOA6IP; nuclear receptor coactivator 6 interacting protein; nuclear receptor coactivator 6-interacting protein; Pimt; PIPMT; PRIP-interacting protein with methyltransferase motif; TGS1; tgs1 {ECO:0000250; Trimethylguanosine synthase; trimethylguanosine synthase 1; trimethylguanosine synthase homolog; trimethylguanosine synthase homolog (S. cerevisiae); trimethylguanosine synthase-like protein; UniProtKB:Q96RS0}
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 96764
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q96RS0
• Gene Symbols: TGS1
• Immunogen: Synthetic peptide directed towards the middle region of human TGS1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov