Invitrogen™ PIMT Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA576285

Catalog No. PIPA576285

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. [UniProt].

Specifications

• Antigen: PIMT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TGS1
• Gene Alias: Cap-specific guanine-N2 methyltransferase; CLL-associated antigen KW-2; D4Ertd800e; HCA137; Hepatocellular carcinoma-associated antigen 137; LOW QUALITY PROTEIN: trimethylguanosine synthase; NCOA6IP; nuclear receptor coactivator 6 interacting protein; nuclear receptor coactivator 6-interacting protein; Pimt; PIPMT; PRIP-interacting protein with methyltransferase motif; TGS1; tgs1 {ECO:0000250; Trimethylguanosine synthase; trimethylguanosine synthase 1; trimethylguanosine synthase homolog; trimethylguanosine synthase homolog (S. cerevisiae); trimethylguanosine synthase-like protein; UniProtKB:Q96RS0}
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116940, 96764
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q923W1, Q96RS0
• Gene Symbols: TGS1
• Immunogen: Recombinant fusion protein of human TGS1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG