Invitrogen™ PINK1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA513402

Catalog No. PIPA513402

Description

PINK1 Polyclonal Antibody for Western Blot, IHC (P)

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.

Specifications

• Antigen: PINK1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PINK1
• Gene Alias: 1190006F07Rik; AU042772; AW557854; BRPK; FLJ27236; mFLJ00387; PARK6; PINK 1; Pink1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
• Host Species: Rabbit
• Purification Method: Ammonium Sulfate Precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 65018
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9BXM7
• Gene Symbols: PINK1
• Immunogen: KLH conjugated synthetic peptide between 118-147 amino acids from the N-terminal region of human PINK1 (PARK6).
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG