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Invitrogen™ PION Polyclonal Antibody
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Catalog No. PIPA521092
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100 μg
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Catalog No. Quantity
PIPA521092 100 μg
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Catalog No. PIPA521092 Supplier Invitrogen™ Supplier No. PA521092
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Description

Rabbit Polyclonal Antibody

A suggested positive control is EL4 cell lysate. PA5-21092 can be used with blocking peptide PEP-1206.

Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for -gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both -gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PION
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene GSAP
Gene Accession No. A4D1B5, Q3TCV3
Gene Alias A530088I07Rik; gamma-secretase activating protein; gamma-secretase-activating protein; Gamma-secretase-activating protein 16 kDa C-terminal form; GSAP; GSAP-16K; pigeon homolog; Pion; Protein pigeon homolog; tcag7.1314
Gene Symbols GSAP
Host Species Rabbit
Immunogen A 19 amino acid peptide near the carboxy terminus of human PION.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 212167, 311984, 54103
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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