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Invitrogen™ PIP5K1A Polyclonal Antibody
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Catalog No. PIPA589199
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100 μL
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PIPA589199 100 μL
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Catalog No. PIPA589199 Supplier Invitrogen™ Supplier No. PA589199
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MNNLLPRSVK MHIKYDLKGS TYKRRASQKE REKPLPTFKD LDFLQDIPDG LFLDADMYNA LCKTLQRDCL VLQSFKIMDY SLLMSIHNID HAQREPLSSE TQYSVDTRRP APQKALYSTA MESIQGEARR GGTMETDDHM GGIPARNSKG ERLLLYIGII DILQSYRFVK KLEHSWKALV HDGDTVSVHR PGFYAERFQR FMCNTVFKKI PCVHLGRPDV LPQTPPLEEI SEGSPIPDPS FSPLVGETLQ MLTTSTTLEK LEVAESEFTH; Positive Samples: A431, Jurkat, Rat spinal cord; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Nucleus speckle, ruffle.

PIP5K1A lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1 is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells. Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through 'frizzled' and 'disheveled', the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP(2) production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes. Overexpression of wild-type PI4P5K1A increases HIV-1 Env-mediated PIP(2) production and enhances viral replication in primary lymphocytes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PIP5K1A
Applications ELISA, Western Blot, Western Blot
Classification Polyclonal
Concentration 1.56 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Pip5k1a
Gene Accession No. D3ZSI8, Q99755
Gene Alias 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; phosphatidylinositol 4-phosphate 5-kinase type I alpha; Phosphatidylinositol 4-phosphate 5-kinase type I beta; Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha; phosphatidylinositol-4-phosphate 5-kinase type I alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha; phosphatidylinositol-4-phosphate 5-kinase, type 1 beta; phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PI4P5K-I[a]; PI4P5KIbeta; PI51A; Pip5k1a; PIP5K1-alpha; Pip5k1b; PIP5KIalpha; Pipk5a; ptdIns(4)P-5-kinase 1 alpha
Gene Symbols Pip5k1a
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 231-500 of human PIP5K1A (NP_0011291091).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 365865, 8394
Target Species Human, Rat, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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