Invitrogen™ PIR-A/PIR-B Monoclonal Antibody (404127)

Catalog No.	Quantity
PIMA524140	100 μg

Catalog No. PIMA524140 Supplier Invitrogen™ Supplier No. MA524140

Description

Rat Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

Paired Ig-like receptors of activating (PIR)-A and -B are expressed on B lymphocytes, macrophages, dendritic cells, platelets, granulocytes, and mast cells, but not on T cells, NK cells, and erythrocytes. These cell surface glycoproteins contain six extracellular Ig-like domains with distinct cytoplasmic and transmembrane regions. The PIR-A receptor activates through signaling molecules containing immunoreceptor tyrosine-based activation motifs. In contrast, the PIR-B receptor inhibits through proteins possessing immunoreceptor tyrosine-based inhibitory motifs. PIRs bind MHC class I to modulate immune system homeostasis and cell signaling.

Specifications

• Antigen: PIR-A/PIR-B
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 404127
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: Pira1
• Gene Accession No.: P97484
• Gene Alias: 6M21; CD85k; cell-surface glycoprotein p91; Gp49b; Gp91; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; Lilrb3; Lilrb4; LIR-3; Ly89; paired Ig-like receptor B; paired immunoglobulin-like receptor; paired immunoglobulin-like receptor B; paired-Ig-like receptor A1; Pir; Pira1; PIR-A1; Pirb; PIR-B
• Gene Symbols: Pira1, Pirb
• Host Species: Rat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse PIR-A1 Gly24-Met650.
• Purification Method: Protein A/G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18722, 18733
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG2a