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Invitrogen™ PIWIL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102687

Catalog No. PIPA5102687


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Description

Description

Antibody detects endogenous levels of total PIWIL2.

The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PIWIL2
Polyclonal
Unconjugated
Piwil2
80kDa PIWIL2 short isoform; cancer/testis antigen 80; CT80; HILI; mili; Miwi like; Miwi likw; piwi like homolog 2; piwi like RNA-mediated gene silencing 2; PIWIL1L; Piwil2; PIWI-L2; piwil2-like protein; piwi-like 2; piwi-like homolog 2; piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; testicular tissue protein Li 141
Rabbit
Affinity chromatography
RUO
306011, 55124, 57746
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q8CDG1, Q8TC59
Piwil2
A synthesized peptide derived from human PIWIL2(Accession Q8TC59), corresponding to amino acid residues C791-E841.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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