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Invitrogen™ PIWIL2 Polyclonal Antibody
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Catalog No. PIPA547854
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100 μg
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PIPA547854 100 μg
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Catalog No. PIPA547854 Supplier Invitrogen™ Supplier No. PA547854
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Description

Sheep Polyclonal Antibody

In direct ELISAs, less than 4% cross-reactivity with recombinant human PIWIL4 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PIWIL2
Applications Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Piwil2
Gene Accession No. Q8TC59
Gene Alias 80kDa PIWIL2 short isoform; cancer/testis antigen 80; CT80; HILI; mili; Miwi like; Miwi likw; piwi like homolog 2; piwi like RNA-mediated gene silencing 2; PIWIL1L; Piwil2; PIWI-L2; piwil2-like protein; piwi-like 2; piwi-like homolog 2; piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; testicular tissue protein Li 141
Gene Symbols Piwil2
Host Species Sheep
Immunogen E. coli-derived recombinant human PIWIL2 Lys216-Asp379.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 306011, 55124
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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