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PKC-alpha Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501562604
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50-156-2604 100 μL
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Catalog No. 50-156-2604 Supplier Bethyl Laboratories, Inc Supplier No. A302445A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat and Rabbit

Members of the Protein kinase C (PKC) family of serine/threonine protein kinases are grouped by their activation mechanism. Classical or conventional PKCs (PKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol. The Ca2+ insensitive novel PKCs (PKCs epsilon-, delta-, theta- and eta) are also activated by diacylglycerol and phosphatidylserine. The atypical PKCs (PKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbolesters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. PKCs are involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP.

Specifications

Antigen PKC-alpha
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene PRKCA
Gene Accession No. P17252
Gene Alias AAG6, aging-associated gene 6, PKCA, PKC-A, PKC-alpha, PRKACA, protein kinase C, alpha
Gene Symbols PRKCA
Host Species Rabbit
Immunogen Between 300 and 350
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5578
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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