PKC iota Mouse anti-Human, Mouse, Rat, Clone: 3A1B6, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 664931IG150UL

Catalog No. 50-173-6916

Description

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Specifications

• Antigen: PKC iota
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: F1M7Y5, P41743, Q62074
• Gene Symbols: Prkci
• Immunogen: PKC iota Fusion Protein Ag4990
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: 3A1B6
• Conjugate: Unconjugated
• Gene: PRKCI
• Gene Alias: aPKC lambda/iota, DXS1179E, PKCI, PRKC lambda/iota, PRKCI, Protein kinase C iota type, protein kinase C, iota
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 18759, 5584, 84006
• Content And Storage: -20°C
• Form: Liquid