PKC iota Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-2379	100 μL

Catalog No. 50-198-2379 Supplier Bioss Supplier No. BS12689R

Description

Rabbit Polyclonal Antibody

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

Specifications

• Antigen: PKC iota
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: PRKCI
• Gene Accession No.: P41743
• Gene Alias: 2310021H13Rik; AI427505; aPKClambda; aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; DXS1179E; mKIAA4165; nPKC-iota; PKCI; Pkcl; PKClambda; Prkci; Prkcl; PRKC-lambda/iota; protein kinase C iota; Protein kinase C iota type; protein kinase C, iota; protein kinase C, lambda; RCJMB04_16p24
• Gene Symbols: PRKCI
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human PKC iota/PKCI.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5584
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG