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Invitrogen™ Polycystin 1 Polyclonal Antibody
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Catalog No. PIPA5115779
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100 μL
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PIPA5115779 100 μL
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Catalog No. PIPA5115779 Supplier Invitrogen™ Supplier No. PA5115779
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Polycystin 1.

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Polycystin 1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Pkd1
Gene Accession No. O08852, P98161
Gene Alias Autosomal dominant polycystic kidney disease 1 protein; autosomal dominant polycystic kidney disease 1 protein homolog; mFLJ00285; PBP; PC1; Pc-1; PKD1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 homolog; polycystic kidney disease 1 homolog; polycystin-1; polycystic kidney disease-associated protein; polycystin 1; polycystin 1, transient receptor potential channel interacting; polycystin-1; transient receptor potential cation channel, subfamily P, member 1; TRPP1
Gene Symbols Pkd1
Host Species Rabbit
Immunogen A synthesized peptide derived from human PKD1(Accession P98161), corresponding to amino acid residues Y2444-E2494.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18763, 24650, 5310
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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