Invitrogen™ Polycystin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115779

Catalog No. PIPA5115779

Description

Antibody detects endogenous levels of total Polycystin 1.

Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.

Specifications

• Antigen: Polycystin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pkd1
• Gene Alias: Autosomal dominant polycystic kidney disease 1 protein; autosomal dominant polycystic kidney disease 1 protein homolog; mFLJ00285; PBP; PC1; Pc-1; PKD1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease 1 homolog; polycystic kidney disease 1 homolog; polycystin-1; polycystic kidney disease-associated protein; polycystin 1; polycystin 1, transient receptor potential channel interacting; polycystin-1; transient receptor potential cation channel, subfamily P, member 1; TRPP1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18763, 24650, 5310
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O08852, P98161
• Gene Symbols: Pkd1
• Immunogen: A synthesized peptide derived from human PKD1(Accession P98161), corresponding to amino acid residues Y2444-E2494.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG