Invitrogen™ PKM1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120660

Catalog No. PIPA5120660

Description

Positive test controls include: Mouse skeletal muscle, Mouse heart, Rat skeletal muscle. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: GSDVANAVLD GADCIMLSGE TAKGDYPLEA VRMQHLIARE AEAAMFHRKL FEELVRASSH STDLMEAMAM GSVEASYKCL AAALIVLTES GRSAHQVARY R.

PKM1 encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.

Specifications

• Antigen: PKM1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKM
• Gene Alias: AA414905; AL024370; AL024424; CTHBP; Cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; HEL-S-30; OIP3; OIP-3; Opa-interacting protein 3; p58; PK, muscle type; PK2; Pk-2; PK3; Pk-3; Pkm; PKM1; PKM12; PKM2; Pykm; Pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; pyruvate kinase muscle isozyme; Pyruvate kinase PKM; pyruvate kinase, muscle; TCB; THBP1; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; tumor M2-PK
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18746, 25630, 5315
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.82 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P11980, P14618, P52480
• Gene Symbols: PKM
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 350-450 of human PKM1-specific (NP_001193728.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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