Invitrogen™ PKN1 Monoclonal Antibody (1B10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA519703

Catalog No. PIMA519703

Description

Peptide Sequence: LDMEPQGCLV AEVTFRNPVI ERIPRLRRQK KIFSKQQGKA FQRARQMNID VATWVRLLRR LIPNATGTGT FSPGASPGSE ARTTGDISVE KLNLGTDSDS SPQKSSRDPP SSPSSLSSPI QESTAPELPS ETQETPGPAL CSPLRKSPLT LEDF.

PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

• Antigen: PKN1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q16512
• Gene Symbols: PKN1
• Immunogen: PKN1 (AAH40061, 462 a.a. ~ 615 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 1B10
• Conjugate: Unconjugated
• Gene: PKN1
• Gene Alias: DBK; F730027O18Rik; PAK1; PAK-1; PKN; PKN1; PKN-ALPHA; PRK1; Prkcl1; Protease-activated kinase 1; protein kinase C-like 1; Protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase N1; protein kinase PKN; protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine/threonine kinase 3; serine/threonine protein kinase N; serine/threonine-protein kinase N1; serine-threonine kinase N; serine-threonine protein kinase N; Stk3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5585
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid