Invitrogen™ PKN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552036

Catalog No. PIPA552036

Description

Immunogen sequence: QKLGLLREAL ERRLGELPAD HPKGRLLREE LAAASSAAFS TRLAGPFPAT HYSTLCKPAP LTGTLEVRVV GCRDLPETIP WNPTPSMGGP GTPDSRPPFL SRPARGLYSR SGSLSGRSSL KAEAENTSEV S Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.

PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

• Antigen: PKN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKN1
• Gene Alias: DBK; F730027O18Rik; PAK1; PAK-1; PKN; PKN1; PKN-ALPHA; PRK1; Prkcl1; Protease-activated kinase 1; protein kinase C-like 1; Protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase N1; protein kinase PKN; protein kinase PKN-alpha; Protein-kinase C-related kinase 1; serine/threonine kinase 3; serine/threonine protein kinase N; serine/threonine-protein kinase N1; serine-threonine kinase N; serine-threonine protein kinase N; Stk3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29355, 320795, 5585
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P70268, Q16512, Q63433
• Gene Symbols: PKN1
• Immunogen: Recombinant protein corresponding to Human PKN1. Recombinant protein control fragment (Product #RP-102277).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov