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Invitrogen™ PKN2 Polyclonal Antibody
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Catalog No. PIPA583248
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100 μL
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PIPA583248 100 μL
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Catalog No. PIPA583248 Supplier Invitrogen™ Supplier No. PA583248
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MASNPERGEI LLTELQGDSR SLPFSENVSA VQKLDFSDTM VQQKLDDIKD RI Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 92%.

PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PKN2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PKN2
Gene Accession No. Q16513
Gene Alias 6030436C20Rik; AI507382; cardiolipin-activated protein kinase Pak2; p140 kinase; PAK2; Pak-2; PKN gamma; PKN2; PRK2; PRKCL2; PRO2042; protease-activated kinase 2; protein kinase C-like 2; protein kinase N2; protein-kinase C-related kinase 2; RP5-905H16.1; serine/threonine kinase 7; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2-like; si:ch211-83f14.1; Stk7; wu:fa97c07
Gene Symbols PKN2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PKN2. Recombinant protein control fragment (Product #RP-97239).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5586
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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