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Invitrogen™ PKN3 Polyclonal Antibody
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Catalog No. PIPA563553
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100 μL
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PIPA563553 100 μL
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Catalog No. PIPA563553 Supplier Invitrogen™ Supplier No. PA563553
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DCIVNMDAPY PGFLSVQGLE FIQKLLQKCP EKRLGAGEQD AEEIKVQPFF RTTNWQALLA RTIQ Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 84%.

PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PKN3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PKN3
Gene Accession No. Q6P5Z2
Gene Alias AW209115; BC034126; Pkn3; PKNBETA; protein kinase N3; protein kinase PKNbeta; protein kinase PKN-beta; protein-kinase C-related kinase 3; Serine/threonine-protein kinase N3; UTDP4-1
Gene Symbols PKN3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PKN3. Recombinant protein control fragment (Product #RP-103324).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29941
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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