Invitrogen™ PKN3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100916

Catalog No. PIPA5100916

Description

Antibody detects endogenous levels of total PKN3.

PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Specifications

• Antigen: PKN3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKN3
• Gene Alias: AW209115; BC034126; Pkn3; PKNBETA; protein kinase N3; protein kinase PKNbeta; protein kinase PKN-beta; protein-kinase C-related kinase 3; Serine/threonine-protein kinase N3; UTDP4-1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 263803, 296619, 29941
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q6P5Z2, Q8K045
• Gene Symbols: PKN3
• Immunogen: A synthesized peptide derived from human PKN3(Accession Q6P5Z2), corresponding to amino acid residues M447-L497.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov