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Invitrogen™ PKNOX2 Polyclonal Antibody
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Catalog No. PIPA5101239
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PIPA5101239 100 μL
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Catalog No. PIPA5101239 Supplier Invitrogen™ Supplier No. PA5101239
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PKNOX2.

PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family. PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1, but displays a more restricted tissue distribution and a higher DNA-dissociation rate. Like PREP-1, PREP-2 forms a heterodimer with Pbx 1. The PREP-2-Pbx 1 dimer is relocated to the nucleus where it associates with HoxB1 to form a ternary complex. In contrast with PREP-1, which acts to increase transcriptional activation in this ternary complex, PREP-2 leads to a slight decrease in transcriptional activity of the ternary complex. Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin and tubulin/microtubules.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PKNOX2
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PKNOX2
Gene Accession No. Q8BG99, Q96KN3
Gene Alias D230005H23Rik; homeobox protein Meis2-like; homeobox protein PKNOX2; Homeobox protein PREP-2; homeodomain containing transcription factor PREP2; Pbx/knotted 1 homeobox 2; PBX/knotted homeobox 2; Pknox2; PREP2
Gene Symbols PKNOX2
Host Species Rabbit
Immunogen A synthesized peptide derived from human PKNOX2(Accession Q96KN3), corresponding to amino acid residues H369-Q419.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 208076, 63876
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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