Invitrogen™ PKNOX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599267

Catalog No. PIPA599267

Description

Antibody detects endogenous levels of total PKNOX2.

PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family. PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1, but displays a more restricted tissue distribution and a higher DNA-dissociation rate. Like PREP-1, PREP-2 forms a heterodimer with Pbx 1. The PREP-2-Pbx 1 dimer is relocated to the nucleus where it associates with HoxB1 to form a ternary complex. In contrast with PREP-1, which acts to increase transcriptional activation in this ternary complex, PREP-2 leads to a slight decrease in transcriptional activity of the ternary complex. Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin and tubulin/microtubules.

Specifications

• Antigen: PKNOX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PKNOX2
• Gene Alias: D230005H23Rik; homeobox protein Meis2-like; homeobox protein PKNOX2; Homeobox protein PREP-2; homeodomain containing transcription factor PREP2; Pbx/knotted 1 homeobox 2; PBX/knotted homeobox 2; Pknox2; PREP2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 208076, 63876
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8BG99, Q96KN3
• Gene Symbols: PKNOX2
• Immunogen: A synthesized peptide derived from human PKNOX2(Accession Q96KN3), corresponding to amino acid residues H369-Q419.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG