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Invitrogen™ PKP2 Polyclonal Antibody
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Catalog No. PIPA566048
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100 μL
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PIPA566048 100 μL
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Catalog No. PIPA566048 Supplier Invitrogen™ Supplier No. PA566048
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NLLTERSTFTD SQLGNADMEM TLERAVSMLE ADHMLPSRIS AAATFIQHEC FQKSEARKRV NQLRGILKLL QLLKVQNEDV QRAVC Highest antigen sequence identity to the following orthologs - mouse 78%, rat 51%.

Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PKP2
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PKP2
Gene Accession No. Q99959
Gene Alias 1200008D14Rik; 1200012P04Rik; AA516617; ARVD9; PKP2; Pkp2l; plakophilin 2; plakophilin-2
Gene Symbols PKP2
Host Species Rabbit
Immunogen Recombinant Human PKP2. Recombinant protein control fragment (Product #RP-106737).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5318
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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