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Invitrogen™ PKP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553144

Catalog No. PIPA553144


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Description

Description

Immunogen sequence: VGNGNLHRTS SVPEYVYNLH LVENDFVGGR SPVPKTYDML KAGTTATYEG RWGRGTAQYS SQKSVEERSL RHPLRRLEIS PDSSPERAHY THSDYQYSQR SQAGHTLHHQ ESRRAALLVP PRY Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 41%.

Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PKP2
Polyclonal
Unconjugated
PKP2
1200008D14Rik; 1200012P04Rik; AA516617; ARVD9; PKP2; Pkp2l; plakophilin 2; plakophilin-2
Rabbit
Antigen affinity chromatography
RUO
5318
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q99959
PKP2
Recombinant protein corresponding to Human PKP2. Recombinant protein control fragment (Product #RP-89628).
100 μL
Primary
Human
Antibody
IgG
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