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Invitrogen™ PKP2 Polyclonal Antibody
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Catalog No. PIPA5102795
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100 μL
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PIPA5102795 100 μL
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Catalog No. PIPA5102795 Supplier Invitrogen™ Supplier No. PA5102795
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PKP2.

Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PKP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PKP2
Gene Accession No. Q99959
Gene Alias 1200008D14Rik; 1200012P04Rik; AA516617; ARVD9; PKP2; Pkp2l; plakophilin 2; plakophilin-2
Gene Symbols PKP2
Host Species Rabbit
Immunogen A synthesized peptide derived from human PKP2(Accession Q99959), corresponding to amino acid residues P105-S155.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 287925, 5318, 67451
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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