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Tocris Bioscience™ PKRA 7
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Catalog No. 62385
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Catalog No. Quantity
62-385 5 mg
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Catalog No. 62-385 Supplier Tocris Bioscience™ Supplier No. 6238/5
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Description

Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

PKRA 7 is a potent prokineticin (PK) receptor antagonist (IC50 values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively). Reduces IL-1β and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models. Also exhibits antiangiogenic activity in vivo. Brain penetrant. Cell-permeable.

Specifications

Chemical Name or Material (3 R)-N-[(9-Chloro-3,4-dihydro-2 H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride
Quantity 5 mg
Target Prokineticin R2/PROKR2
Molecular Formula C27H34ClFN2O4.HCl
Purity 0.98
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