Invitrogen™ PLA1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA534460

Catalog No. PIPA534460

Description

A suggested positive control is human kidney tissue lysate. PA5-34460 can be used with blocking peptide PEP-1502.

PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.

Specifications

• Antigen: PLA1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLA1A
• Gene Alias: AA986889; NMD; Phosphatidylserine-specific phospholipase A1; phosphatidylserine-specific phospholipase A1alpha; phospholipase A1 member A; PLA1A; PSPLA1; PS-PLA1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51365, 85311
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P97535, Q53H76
• Gene Symbols: PLA1A
• Immunogen: A 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov