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Invitrogen™ PLA1A Polyclonal Antibody
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Catalog No. PIPA566277
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PIPA566277 100 μL
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Catalog No. PIPA566277 Supplier Invitrogen™ Supplier No. PA566277
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QCQINQVKFKF QSSNRVWKKD RTTIIGKFCT ALLPVNDREK MVCLPEPVNL QASVTVSCDL KIAC Highest antigen sequence identity to the following orthologs - mouse 71%, rat 68%.

PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLA1A
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PLA1A
Gene Accession No. Q53H76
Gene Alias AA986889; NMD; Phosphatidylserine-specific phospholipase A1; phosphatidylserine-specific phospholipase A1alpha; phospholipase A1 member A; PLA1A; PSPLA1; PS-PLA1
Gene Symbols PLA1A
Host Species Rabbit
Immunogen Recombinant Human PLA1A. Recombinant protein control fragment (Product #RP-106963).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51365
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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