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Invitrogen™ PLA1A Polyclonal Antibody
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Catalog No. PIPA5104279
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100 μL
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PIPA5104279 100 μL
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Catalog No. PIPA5104279 Supplier Invitrogen™ Supplier No. PA5104279
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PLA1A.

PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLA1A
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PLA1A
Gene Accession No. P97535, Q53H76, Q8VI78
Gene Alias AA986889; NMD; Phosphatidylserine-specific phospholipase A1; phosphatidylserine-specific phospholipase A1alpha; phospholipase A1 member A; PLA1A; PSPLA1; PS-PLA1
Gene Symbols PLA1A
Host Species Rabbit
Immunogen A synthesized peptide derived from human PLA1A(Accession Q53H76), corresponding to amino acid residues I257-I307.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51365, 85031, 85311
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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