PLA2R1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587610

Catalog No. PIPA587610

Description

Immunogen sequence: GASWWIGLQE ERANDEFRWR DGTPVIYQNW DTGRERTVNN QSQRCGFISS ITGLWGSEEC SVSMPSICKR KKVWLIEKKK DTPKQHGTCP KGWLYFNYKC LLLNIPKDPS SWKNWTHAQH FCAEEGGTLV AIESEVEQAF ITMNLFGQTT SVWIGLQNDD YETWLNGKPV VYSNWSPFDI INIPSHNTTE VQKHIPLCAL LSSNPNFHFT GKWYFEDCGK EGYGFVCEKM QDTSGHGVNT SDMYPMPNTL EYGNRTYKII N; Positive Samples: 293T, SH-SY5Y, Mouse liver, Mouse heart; Cellular Location: Cell membrane, Single-pass type I membrane protein

Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.

Specifications

• Antigen: PLA2R1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Pla2r1
• Gene Alias: 180 kDa secretory phospholipase A2 receptor, CLEC13C, C-type lectin domain family 13 member C, mannose receptor, C type 2, Mrc2, M-type receptor, phospholipase A2 receptor 1, phospholipase A2 receptor 1, 180kD, phospholipase A2 receptor 1, 180kDa, phospholipase A2, group IB, pancreas, receptor, Pla2g1br, PLA2G1R, PLA2-I receptor, PLA2IR, Pla2r, Pla2-r, PLA2R1, Secretory phospholipase A2 receptor, Soluble PLA2-R, Soluble secretory phospholipase A2 receptor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22925
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.37 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300, pH 7.3
• Gene Accession No.: Q13018
• Gene Symbols: Pla2r1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 870-1130 of human PLA2R1 (NP_0313923)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov