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Invitrogen™ Placental Alkaline Phosphatase Polyclonal Antibody
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Catalog No. PIPA578764
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100 μg
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PIPA578764 100 μg
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Catalog No. PIPA578764 Supplier Invitrogen™ Supplier No. PA578764
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human placenta tissue, human placenta tissue. IHC: human placenta tissue. ICC/IF: HELA cell. Flow: SiHa cell.

Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Placental Alkaline Phosphatase
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene ALPP
Gene Accession No. P05187
Gene Alias Alkaline phosphatase placental type; Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental; alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; Alp1; ALPP; AP-TNAP; DOA1; FLJ11281; FLJ40094; FLJ61142; FLJ93059; Germ-cell alkaline phosphatase; glycerophosphatase; HOPS; MGC161443; MGC167935; nagao Isozyme; P PLAP; PALP; PLA2P; PLAA; placental alkaline phosphatase 1; placental heat-stable alkaline phosphatase; PLAP; PLAP1; PLAP-1; rCG23846-like; Regan isozyme; TNAP; TNSALP
Gene Symbols ALPP
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human ALPP (403-433aa KARDRKAYTVLLYGNGPGYVLKDGARPDVTE).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 250
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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