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Placental Alkaline Phosphatase Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984397
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50-198-4397 100 μL
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Catalog No. 50-198-4397 Supplier Bioss Supplier No. BS20015R
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Description

Rabbit Polyclonal Antibody

Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.

Specifications

Antigen Placental Alkaline Phosphatase
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene ALPP
Gene Accession No. P05187, P10696
Gene Alias Akp5; Alkaline phosphatase 5; Alkaline phosphatase Nagao isozyme; Alkaline phosphatase Regan isozyme; Alkaline phosphatase, germ cell type; alkaline phosphatase, placental; alkaline phosphatase, placental like 2; Alkaline phosphatase, placental type; Alkaline phosphatase, placental-like; alkaline phosphatase, placental-like 2; alkaline phosphomonoesterase; ALP; ALP-1; Alpg; ALPP; ALPPL; Alppl2; AP-TNAP; C77216; D1Ertd816e; DOA1; Eap; Embryonic alkaline phosphatase; Embryonic-type alkaline phosphatase; FLJ11281; FLJ40094; FLJ61142; FLJ93059; GCAP; Germ cell alkaline phosphatase; glycerophosphatase; HOPS; MGC161443; MGC167935; Nagao isozyme; P PLAP; PALP; PLA2P; PLAA; Placental alkaline phosphatase 1; Placental alkaline phosphatase-like; placental-like alkaline phosphatase; PLAP; PLAP-1; PLAP-like; Regan isozyme; testicular and thymus alkaline phosphatase; TNAP; TNSALP
Gene Symbols ALPG, ALPP
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Placental alkaline phosphatase 1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 250, 251
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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