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Plakophilin 2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981072
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50-198-1072 100 μL
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Catalog No. 50-198-1072 Supplier Bioss Supplier No. BS11063R
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Description

Rabbit Polyclonal Antibody

Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.

Specifications

Antigen Plakophilin 2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PKP2
Gene Accession No. Q99959
Gene Alias 1200008D14Rik; 1200012P04Rik; AA516617; ARVD9; PKP2; Pkp2l; plakophilin 2; Plakophilin-2
Gene Symbols PKP2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Plakophilin 2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5318
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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