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PLAP Mouse anti-Human, Clone: 2B7C9, Proteintech
SDP

Catalog No. 501736389 Shop All Proteintech Group Inc Products
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50-173-6389 150 μL
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Catalog No. 50-173-6389 Supplier Proteintech Group Inc Supplier No. 602941IG150UL
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Description

Mouse Monoclonal Antibody

Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized.Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.

Specifications

Antigen PLAP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2B7C9
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ALPP
Gene Accession No. P05187
Gene Alias ALP, ALPP, PALP, Placental alkaline phosphatase, PLAP, PLAP 1
Gene Symbols ALPP
Host Species Mouse
Immunogen PLAP Fusion Protein Ag13361
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 250
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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