Plasma Cell Antibody (LIV3G11 (7B18)), Alexa Fluor™ 594, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP233162AF594

Catalog No. NB005717

Description

Plasma Cell Monoclonal specifically detects Plasma Cell in Human, Rat (Negative) samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

• Antigen: Plasma Cell
• Classification: Monoclonal
• Conjugate: Alexa Fluor 594
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Rat (Negative)
• Isotype: IgG2a κ

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
• Clone: LIV3G11 (7B18)
• Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
• Gene Alias: Plasma
• Immunogen: Pancreatic cancer related serum mucin was used as the immunogen for the Plasma Cell antibody.
• Quantity: 0.1 mL
• Research Discipline: Immunology
• Test Specificity: It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This monoclonal antibody superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this monoclonal antibody is not suitable for staining frozen tissues.
• Content And Storage: Store at 4°C in the dark.