Invitrogen™ Plasma Kallikrein Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA592392

Catalog No. PIPA592392

Description

Immunogen sequence: GCLTQLYENA FFRGGDVASM YTPNAQYCQM RCTFHPRCLL FSFLPASSIN DMEKRFGCFL KDSVTGTLPK VHRTGAVSGH SLKQCGHQIS ACHRDIYKGV DMRGVNFNVS KVSSVEECQK RCTSNIRCQF FSYATQTFHK AEYRNNCLLK YSPGGTPTAI KVLSNVESGF SLKPCALSEI GCHMNIFQHL AFSDVDVARV LTPDAFVCRT ICTYHPNCLF FTFYTNVWKI ESQRNVCLLK TSESGTPSSS TPQENTISGY SLLTCKRTLP EPCHSKIYPG V; Positive Samples: Mouse liver, Mouse intestine, Mouse brain.

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Specifications

• Antigen: Plasma Kallikrein
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Klkb1
• Gene Alias: antigen, prostate specific; APS; EC 3.4.21.34; Fletcher factor; Kal3; Kal-3; kallikrein; kallikrein 3, plasma; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; kallikrein B, plasma 1; kallikrein B1; Kalp1; KALP15; kininogenin; Klk3; KLKB1; Pk; PKK; PKKD; plasma kallikrein; Plasma kallikrein heavy chain; Plasma kallikrein light chain; Plasma prekallikrein; PPK; prekallikrein; PSA
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16621, 25048, 3818
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.16 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: P03952, P14272, P26262
• Gene Symbols: Klkb1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human KLKB1 (NP_0008832).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG