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Invitrogen™ Plasma Kallikrein Polyclonal Antibody

Catalog No. PIPA5120203
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100 μL
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PIPA5120203 100 μL
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Catalog No. PIPA5120203 Supplier Invitrogen™ Supplier No. PA5120203
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HT-29, 293T, BxPC-3, Mouse liver, Mouse pancreas , Rat liver. The target is usually found in the following locations: Secreted. Immunogen sequence: IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG NHDIALIKLQ APLNYTEFQK.

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Plasma Kallikrein
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene Klkb1
Gene Accession No. P03952, P14272, P26262
Gene Alias antigen, prostate specific; APS; EC 3.4.21.34; Fletcher factor; Kal3; Kal-3; kallikrein; kallikrein 3, plasma; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; kallikrein B, plasma 1; kallikrein B1; Kalp1; KALP15; kininogenin; Klk3; KLKB1; Pk; PKK; PKKD; plasma kallikrein; Plasma kallikrein heavy chain; Plasma kallikrein light chain; Plasma prekallikrein; PPK; prekallikrein; PSA
Gene Symbols Klkb1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 391-500 of KLKB1 (NP_000883.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16621, 25048, 3818
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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