Plasminogen Monoclonal Antibody (8E7), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA120081

Catalog No. PIMA120081

Description

MA1-20081 detects plasminogen in human samples.

Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.

Specifications

• Antigen: Plasminogen
• Classification: Monoclonal
• Concentration: 9 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P00747
• Gene Symbols: PLG
• Immunogen: Purified, full length, native, human plasminogen protein.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Affinity Purification, ELISA, Immunohistochemistry (Paraffin)
• Clone: 8E7
• Conjugate: Unconjugated
• Gene: PLG
• Gene Alias: Ab1-346; Activation peptide; AI649309; angiostatin; DKFZp779M0222; Pg; plasmin; plasmin heavy chain A; Plasmin heavy chain A, short form; Plasmin light chain B; plasminogen; PLG; RP1-81D8.1
• Host Species: Mouse
• Purification Method: IgG fraction
• Regulatory Status: RUO
• Gene ID (Entrez): 5340
• Content And Storage: 4° C
• Form: Liquid