Plasminogen, MP Biomedicals™

Description

Found in human plasma (∼150mg/ml) and extracellular fluid. Plasminogen, MP Biomedicals is a single-chain plasma glycoprotein. Some activators (e.g. tissue plasminogen activator) convert plasminogen to its active form, plasmin. Plasminogen has been use

Two forms of plasminogen exist, namely the original form Glu-Plg and Lys-Plg. Activators such as tPA and scuPA are able to transform plasminogen into the two-chain plasmin, which expresses its enzymatic activity. Free plasmin in plasma will be inactivated immediately by its specific inhibitor, alpha-2-antiplasmin. Normally, plasmin only acts in the fibrin clot to degrade it.

Plasminogen is the inactive precursor of the protease plasmin. It is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.

Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

Specifications

Chemical Identifiers

• CAS: 9001-91-6
• Synonym: Profibrinolysin

• Quantity: 250 U
• Formula Weight: 90,000-94,000
• Percent Purity: ≥95%
• Physical Form: Solid

Safety and Handling

Recommended Storage

−20°C

WARNING: Reproductive Harm - www.P65Warnings.ca.gov