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Platelet GPVI Mouse anti-Human, Brilliant Violet 786, Clone: HY101 (also known as HY 101; HY-101), BD Optibuild™

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BDB743946 50 μg
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Catalog No. BDB743946 Supplier BD Biosciences Supplier No. 743946
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Description

Mouse Monoclonal Antibody

The HY101 monoclonal antibody specifically binds to a collagen receptor, Platelet Glycoprotein VI (GPVI or GP6). GPVI is a 58-kD platelet membrane glycoprotein that belongs to the immunoglobulin superfamily. Upon blood vessel wall injury and consequent endothelial cell damage, platelets collect upon the exposed collagen fibers present in the subendothelial matrix. The platelet and collagen interaction leads to activated platelet aggregation and thrombus formation. Although normally serving a protective function in clot formation that limits blood loss, the platelet GPVI/collagen interaction may also play a role in myocardial infarction and stroke which are associated with the rupture of atherosclerotic plaques.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Platelet GPVI
Classification Monoclonal
Clone HY101 (also known as HY 101; HY-101)
Concentration 0.2mg/mL
Conjugate Brilliant Violet 786
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Glycoprotein 6, GP6, Platelet glycoprotein VI, Platelet collagen receptor
Host Species Mouse
Immunogen Glycoprotein VI Recombinant Protein
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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