PLAU Mouse anti-Human, Clone: OTI1D4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF805314

Catalog No. 50-166-7375

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer′s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: PLAU
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PLAU
• Gene Alias: ATF, BDPLT5, QPD, UPA, URK, u-PA
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5328
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI1D4
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P00749
• Gene Symbols: PLAU
• Immunogen: Human recombit protein fragment corresponding to amino acids 107-379 of human PLAU produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1