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PLAU Mouse anti-Human, Clone: OTI1D4, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF805314

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer′s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Specifications
PLAU | |
Monoclonal | |
Unconjugated | |
PLAU | |
ATF, BDPLT5, QPD, UPA, URK, u-PA | |
Mouse | |
Affinity Chromatography | |
RUO | |
5328 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI1D4 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
P00749 | |
PLAU | |
Human recombit protein fragment corresponding to amino acids 107-379 of human PLAU produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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