PLCE1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5100856

Catalog No. PIPA5100856

Description

Antibody detects endogenous levels of total PLCE1.

This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Specifications

• Antigen: PLCE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLCE1
• Gene Alias: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; 4933403A21Rik; KIAA1516; mKIAA1516; NPHS3; pancreas-enriched phospholipase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1; phospholipase C epsilon 1; phospholipase C, epsilon 1; phospholipase C-epsilon-1; PLCE; PLCE1; PLCepsilon; PLC-epsilon-1; PPLC
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114633, 51196, 74055
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8K4S1, Q99P84, Q9P212
• Gene Symbols: PLCE1
• Immunogen: A synthesized peptide derived from human PLCE1(Accession Q9P212), corresponding to amino acid residues R2267-Q2302.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Non-human Primate, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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