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Invitrogen™ PLD6 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA571510
Description
PLD6 Polyclonal Antibody for Western Blot
PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
Specifications
PLD6 | |
Polyclonal | |
Unconjugated | |
PLD6 | |
4933433K01Rik; choline phosphatase 6; Gm10; Mitochondrial cardiolipin hydrolase; mitochondrial phospholipase; mitoPLD; mZuc; novel Phospholipase D Active site motif-containing protein; phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family member 6; phospholipase D family, member 6; phospholipase D6; PLD 6; PLD6; Protein zucchini homolog; Zuc | |
Rabbit | |
Antigen affinity chromatography, Protein A | |
RUO | |
194908, 201164 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
0.5 mg/mL | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q5SWZ9, Q8N2A8 | |
PLD6 | |
KLH conjugated synthetic peptide between 125-154 amino acids from of human PLD6. | |
400 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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