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Invitrogen™ PLD6 Polyclonal Antibody
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Catalog No. PIPA571510
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400 μL
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PIPA571510 400 μL
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Catalog No. PIPA571510 Supplier Invitrogen™ Supplier No. PA571510
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Description

Rabbit Polyclonal Antibody

PLD6 Polyclonal Antibody for Western Blot

PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLD6
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene PLD6
Gene Accession No. Q5SWZ9, Q8N2A8
Gene Alias 4933433K01Rik; choline phosphatase 6; Gm10; Mitochondrial cardiolipin hydrolase; mitochondrial phospholipase; mitoPLD; mZuc; novel Phospholipase D Active site motif-containing protein; phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family member 6; phospholipase D family, member 6; phospholipase D6; PLD 6; PLD6; Protein zucchini homolog; Zuc
Gene Symbols PLD6
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 125-154 amino acids from of human PLD6.
Purification Method Antigen affinity chromatography, Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 194908, 201164
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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