Invitrogen™ PLD6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113180

Catalog No. PIPA5113180

Description

PLD6 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), ELISA

PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.

Specifications

• Antigen: PLD6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLD6
• Gene Alias: 4933433K01Rik; choline phosphatase 6; Gm10; Mitochondrial cardiolipin hydrolase; mitochondrial phospholipase; mitoPLD; mZuc; novel Phospholipase D Active site motif-containing protein; phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family member 6; phospholipase D family, member 6; phospholipase D6; PLD 6; PLD6; Protein zucchini homolog; Zuc
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 194908, 201164
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q5SWZ9, Q8N2A8
• Gene Symbols: PLD6
• Immunogen: Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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