Invitrogen™ Plectin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556292

Catalog No. PIPA556292

Description

Immunogen sequence: TEIIRQQGLA SYDYVRRRLT AEDLFEARII SLETYNLLRE GTRSLREALE AESAWCYLYG TGSVAGVYLP GSRQTLSIYQ ALKKGLLSAE VARLLLEAQA A Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 92%.

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes. Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans. The expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development and it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms which carry out distinct and specific functions.

Specifications

• Antigen: Plectin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Plec
• Gene Alias: AA591047; AU042537; EBS1; EBSMD; EBSND; EBSO; EBSOG; EBSPA; HD1; Hemidesmosomal protein 1; LGMD2Q; PCN; Plec; PLEC1; PLEC1b; Plectin; plectin 1; plectin 1, intermediate filament binding protein 500kDa; plectin-1; Plectin-6; Pltn
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5339
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q15149
• Gene Symbols: Plec
• Immunogen: Recombinant protein corresponding to Human Plectin. Recombinant protein control fragment (Product #RP-93970).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG