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Invitrogen™ PLEKHG6 Polyclonal Antibody
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Catalog No. PA550458
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100 μL
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PA550458 100 μL
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Catalog No. PA550458 Supplier Invitrogen™ Supplier No. PA550458
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total PLEKHG6 protein.

PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLEKHG6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 2.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene PLEKHG6
Gene Accession No. Q3KR16
Gene Alias BC026778; Gm155; MyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; myosin-interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; pleckstrin homology and RhoGEF domain containing G6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; pleckstrin homology domain-containing family G member 6; PLEKHG6
Gene Symbols PLEKHG6
Host Species Rabbit
Immunogen Fusion protein corresponding to a region derived from internal residues of human pleckstrin homology domain containing, family G (with RhoGef domain) member 6.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55200
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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