Invitrogen™ PLEKHG6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559578

Catalog No. PIPA559578

Description

Immunogen sequence: GLLMEVSAET LFGNVPSLIR THRSFWDEVL GPTLEETRAS GQPLDPIGLQ SGFLTFGQRF HPYVQYCLRV KQTMAYAREQ QETNPLFHAF VQWCE Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 83%.

PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Specifications

• Antigen: PLEKHG6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLEKHG6
• Gene Alias: BC026778; Gm155; MyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; myosin-interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; pleckstrin homology and RhoGEF domain containing G6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; pleckstrin homology domain-containing family G member 6; PLEKHG6
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55200
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q3KR16
• Gene Symbols: PLEKHG6
• Immunogen: Recombinant protein corresponding to Human PLEKHG6. Recombinant protein control fragment (Product #RP-97628).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov