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Invitrogen™ PLEKHM1 Polyclonal Antibody
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Catalog No. PIPA558800
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100 μL
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PIPA558800 100 μL
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Catalog No. PIPA558800 Supplier Invitrogen™ Supplier No. PA558800
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PARIIHNWDL TKRPICRQAL KFLTQIRAQP LINLQMVNAS LYEHVERMHL IGR Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

PLEKHM1 is a member of the M family of Pleckstrin homolog domain-containing proteins, a group of proteins containing a RUN domain, two pleckstrin homology domains, and a cysteine-rich domain. It was identified through segregation analysis as a cause of osteopetrosis in humans. PLEKHM1 co-localizes with Rab7 to late endosomal/lysosomal vesicles in HEK293 and osteoclast-like cells, with this co-localization dependent on the prenylation of Rab7. Monocytes from a patient homozygous for a mutated form of PLEKHM1differentiated into osteoclasts normally, but failed to form ruffled borders and showed little evidence of bone resorption when cultured on dentine discs. Another mutation of PLEKHM1 impaired vesicular acidification and increased TRACP secretion in osteoclasts, suggesting that PLEKHM1 has critical roles in endosomal maturation and may be important in osteoclast-osteoblast cross-talk.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLEKHM1
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PLEKHM1
Gene Accession No. Q9Y4G2
Gene Alias 162 kDa adapter protein; AP162; B2; BC038943; D330036J23Rik; KIAA0356; OPTB6; PH domain-containing family M member 1; pleckstrin homology and RUN domain containing M1; pleckstrin homology domain containing, family M (with RUN domain) member 1; pleckstrin homology domain-containing family M member 1; PLEKHM1
Gene Symbols PLEKHM1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PLEKHM1. Recombinant protein control fragment (Product #RP-102873).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9842
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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