PLIN5 Monoclonal Antibody (OTI4C8), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-4159	100 μL

Catalog No. 50-168-4159 Supplier OriGene Supplier No. TA811642

Description

Mouse Monoclonal Antibody

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.

Specifications

• Antigen: PLIN5
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI4C8
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: PLIN5
• Gene Accession No.: Q00G26
• Gene Alias: LSDA5, LSDP5, MLDP, OXPAT
• Gene Symbols: PLIN5
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-463 of human PLIN5 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 440503
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a