PLK1 Mouse anti-Canine, Human, Clone: OTI8C12, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF500393

Catalog No. 50-165-9470

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

PLK1 is a Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.

Specifications

• Antigen: PLK1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: PLK1
• Gene Alias: PLK, STPK13
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 489971, 5347
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
• Clone: OTI8C12
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P53350
• Gene Symbols: PLK1
• Immunogen: Full-length protein expressed in 293T cell transfected with human PLK1 expression vector
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Canine, Human
• Product Type: Antibody
• Isotype: IgG1